Capsazepine was developed to block TRPV1, a calcium channel found in pain-sensing neurons. Study first author Cara B. Gonzales, DDS, PhD, assistant professor of comprehensive dentistry and an investigator with the Cancer Therapy & Research Center at the UT Health Science Center at San Antonio, found that capsazepine also has anti-cancer activity that could be associated with its ability to increase damage in tumors.
The study found that capsazepine was highly effective in suppressing tumor growth and did not show any identifiable toxicities. Thus far, only local administration of capsazepine, directly into the primary tumors, has been tested.
“Capsazepine kills cancers selectively, leaving normal tissues alone, and also acts on neurons to block pain, a desirable combination in a potential medication,” said Dr. Gonzales.
More articles on physician news:
The CORE Institute enters into co-management with Providence Hospitals
Who’s been working with the stars? 10 orthopedic surgeries for professional athletes
21 spine, neurosurgeons on the move
At the Becker's 5th Annual Future of Dentistry Roundtable, taking place September 14-15 in Chicago, dental leaders and executives will gain insights into emerging technologies, practice growth strategies and the evolving landscape of dental care delivery, with a focus on innovation, patient experience and operational excellence. Apply for complimentary registration now.
